Why Smart People Are Stupid

I am not a psychiatrist nor a psychologist. I do, however, have an explanation I find logical for why both of these questions would get wrong answers.

A bat and ball cost a dollar and ten cents. The bat costs a dollar more than the ball. How much does the ball cost?

The reason this "problem" will yield a common answer of 1 dollar is because so many of us have seen the same thing over and over in school. It has been over the course of 5+ years engraved into our thought process to separate pieces of the sentence into logical portions and stop as soon as we have enough information (ie: to assume most of it is useless information). So as soon as the reader sees the intentionally deceptively worded sentence, it's effectively an expected response from this programmed behavior: most people stop where I'm about to show you:

A bat and a ball cost a dollar and ten cents. The bat costs a dollar --

Immediately, we have a situation: a + b = 110, a = 100. We immediately deduce that b = 10, and have a solution instantaneously without completing the thought. This is what standardized testing and predictable word problems with extraneous information teaches people. This isn't a result of their intelligence, this is a result of cognitive process sculpted by years of stupid, pointless exercises. You'd have to be outrageously stupid to think this is somehow unexpected. The people who we classify as "smart" are people who perform well at these tasks (high score on standardized test, breezed through courses with similar problems). This is causation -- people who make this mental leap are considered "smart." So you ask "why are all these smart people making this stupid mistake!?" The answer is clear -- your fundamental measure of intelligence is wrong. The solution is that these so-called "smart" people aren't very smart at all. They're just good at solving tricky word problems as quickly as possible, primarily by ignoring information. In my experience, this methodology is often the inverse of an intelligent process.

Now for the second problem:

In a lake, there is a patch of lily pads. Every day, the patch doubles in size. If it takes 48 days for the patch to cover the entire lake, how long would it take for the patch to cover half of the lake?

What most people will do, because this is how they've been taught, is to read sentence one. Note it as an interesting fact, then proceed. Upon finishing the second sentence, we realize we didn't come up with an answer yet, so we refer to only the information in the latter part of the question. What most people just read is:

If it takes 48 days for the patch to cover the entire lake, how long would it take for the patch to cover half of the lake?

We aren't used to thinking in terms of exponentiation, so it's natural to assume a linear growth rate when you completely discard the first sentence.

While I agree, these are both absurd questions, they have something in common: people tend to ignore part of the question and answer the question with incomplete information. This is not something I do very often, intentionally. This is something, though, that I recall being the fundamental "trick" to answering 99.99999999999% of questions on standardized tests. They gave you extraneous information. When literally every problem exposed to you has extraneous information, of 2 forms: A, B or B, A, where B = worthless information, it becomes habitual to process information in this manner, especially when the problem is worded like a problem you'd find on a high-school level standardized test (you know, you never really forget how to ride a bike, like you never forget how to solve very badly designed problems that don't test intelligence in any way).

I don't know, maybe I'm too smart for this researcher. But the answer seems obvious: years and yea

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The Ins And Outs Of The Forex Market | Finance News

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Summit Entertainment Celebrates Summer With Music From "Step ...

Summit Entertainment Celebrates Summer With Music From "Step Up Revolution"

Jennifer Lopez featuring Flo Rida to appear on film soundtrack with new single "Goin' In"

SANTA MONICA, Calif., June 11, 2012 /PRNewswire/ -- Summit Entertainment's upcoming summer release STEP UP REVOLUTION will highlight Jennifer Lopez's hotly anticipated new track, "Goin' In" featuring Flo Rida with additional vocals by Lil Jon and production by GoonRock on the film soundtrack. The single will be available in the U.S. through iTunes on June 12, 2012 with the soundtrack dropping on July 10, 2012. "Goin' In" is scheduled for release today, June 11, 2012 in most international territories. Lopez debuted the single on the May 23rd season finale of Fox's AMERICAN IDOL.

"Jennifer Lopez and Flo Rida are two of the leading artists in the music industry today," said Lionsgate Motion Picture Group President of Production Erik Feig, who is also the film's producer. "Jennifer's foundation in dance paired with her impeccable ear for hot dance beats perfectly capture the style and spirit of STEP UP REVOLUTION while having Flo Rida back to contribute to this soundtrack after his successes on the previous installments of the franchise is a winning combination."

STEP UP REVOLUTION is the newest installment of the worldwide hit STEP UP franchise, which sets its dancing against the vibrant backdrop of Miami. Emily (Kathryn McCormick) arrives in Miami with aspirations of becoming a professional dancer and soon falls in love with Sean (Ryan Guzman), a young man who leads a dance crew in elaborate, cutting-edge flash mobs, called "The Mob." When a wealthy businessman threatens to develop The Mob's historic neighborhood and displace thousands of people, Emily must band together with Sean and The Mob to turn their performance art into protest art, and risk losing their dreams to fight for a greater cause.

Summit Entertainment, a LIONSGATE company, will release the motion picture nationwide on July 27, 2012.

Art from the film is available at www.summitpublicity.com

ABOUT SUMMIT ENTERTAINMENT, LLC
Summit Entertainment, a LIONSGATE? company, is a worldwide theatrical motion picture development, financing, production and distribution studio. The company handles all aspects of marketing and distribution for both its own internally developed motion pictures as well as acquired pictures.

Lionsgate is a leading global entertainment company with a strong and diversified presence in motion picture production and distribution, television programming and syndication, home entertainment, family entertainment, digital distribution, new channel platforms and international distribution and sales. The Company has built a strong television presence in production of primetime cable and broadcast network series, distribution and syndication of programming and an array of channel assets. Lionsgate currently has 23 shows on 16 networks spanning its primetime production, distribution and syndication businesses, including such critically-acclaimed hits as the multiple Emmy Award-winning "Mad Men," "Weeds" and "Nurse Jackie," along with the drama "Boss," the new network series "Nashville" and "Next Caller," the syndication successes "Tyler Perry's House of Payne," its spinoff "Meet the Browns," "The Wendy Williams Show" and "Are We There Yet?" and the upcoming "Anger Management," starring Charlie Sheen, and "Orange Is The New Black," an original series for Netflix.

Its feature film business has been fueled by such recent successes as the blockbuster first installment of "The Hunger Games" franchise, which has already grossed nearly $650 million at the worldwide box office, "The Expendables," "The Lincoln Lawyer", "Cabin In The Woods," "Tyler Perry's Madea's Big Happy Family" and "Margin Call." With the January 2012 acquisition of Summit Entertainment, the Company now has added the blockbuster "Twilight Saga" franchise, which has grossed more than $2.5 billion at the worldwide box office, to a slate already including "The Hunger Games," giving Lionsgate the two premier young adult franchises in the world. Recent Summit hits include "Red," "Letters to Juliet," "Knowing," the "Step Up" franchise and the Academy Award-winning Best Picture, "The Hurt Locker."

Lionsgate's home entertainment business is an industry leader in box office-to-DVD and box office-to-VOD revenue conversion rate. Lionsgate handles a prestigious and prolific library of approximately 13,000 motion picture and television titles that is an important source of recurring revenue and serves as the foundation for the growth of the Company's core businesses. The Lionsgate and Summit brands remain synonymous with original, daring, quality entertainment in markets around the world.

ABOUT JENNIFER LOPEZ
International icon Jennifer Lopez is an entertainer, recording artist, film actress, producer, fashion designer, entrepreneur and philanthropist. Lopez has sold over 70 million RIAA certified records worldwide and has starred in multiple #1 box office films including "The Wedding Planner" and "Monster-In-Law." She has achieved global landmark success and broken records for her music. Last year, "On The Floor" became the Most Watched Music Video by a female artist in the history of YouTube, and she has accumulated a staggering 1 billion video views in her career.

JLO's music has reached every continent in the world, transcending borders and languages. Her music and celebrity have struck a common chord with all generations and all walks of life. With #1 singles, #1 albums, #1 music videos, #1 TV shows and #1 box-office smashes, Jennifer Lopez is the definition of an icon. The Wedding Planner was the nation's top grossing film in 2001, while her album, JLO, was #1 on the Billboard Top 200 Chart. The two simultaneous #1 honors made Lopez the first woman in history to have a #1 movie and album in the same week.

Lopez has also set the standard for celebrity branding in fragrance, apparel and accessories. She has launched worldwide campaigns as the ambassador of L'Oreal and Venus Gillette and many more. In 2011, she achieved another milestone with the successful launch of an exclusive fashion collection with Kohl's. Her new fragrance, Glowing, marks the 18th successful launch of a string of fragrances with combined sales exceeding $2 billion. Jennifer founded her "Maribel Foundation" along with her sister, Lynda, and for years has been dedicated to improving the health and well-being of women and children and raising the level of medical care available to them. Coming full circle, Jennifer has been named the spokeswoman of the Boys & Girls Club of America, the same organization whose benefits she enjoyed as a girl growing up in the Bronx. 2012 will mark another first, with Lopez embarking on the most extensive concert tour of her career. Follow Jennifer on Twitter: @JLO
www.jenniferlopez.com

CONTACT

For Summit Entertainment:
Hans-Dieter Kopal
323-658-1555
hans@pcommgroup.com

For Jennifer Lopez:
Mark Young
917-826-6650
myoung@thefactoryinc.com

SOURCE Summit Entertainment

Summit Entertainment

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HBT: Trout having an insane rookie season

So much has been said about Bryce Harper, but Mike Trout is having just as insane a rookie season.

Last night Trout either drove in or scored all of the Angels? runs. The last one was set up by him drawing a walk and then stealing second base. Throw in the earlier homer (and an earlier stolen base) and you?re aware of just how complete a package this kid is.

Trout leads the AL in stolen bases besides being in the minors for almost the entire month of April. Since he?s been called up he?s been an on-base machine. And the Angels have gone 27-15 and find themselves a mere 2.5 games out of first place.

There are reasons why we are hearing more about Harper than Trout. Harper was on the cover of SI when he was 16 and was the number one overall pick. Most of his games are played and end when most of the sporting press is awake. ?But let?s not forget about this kid out west. Because he?s been absolutely astounding.

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Importance of Packers and Movers in Real Estate

Real Estate has proven to be a new sector that is evolving each day and is operating its business in almost all the major Indian cities and towns; such as Ahmadabad, Allahabad, Agra, Aurangabad, Bangalore, Bhopal, Bhatinda, Chennai, Cochin, Chandigarh, Dehradun, Dhanbad, Faridabad, Ghaziabad, Goa, Gurgaon, Gandhinagar, Hissar, Haridwar, Hyderabad, Indore, Jaipur, Jalandhar, Kolkata, Kanpur, Karnal, Lucknow, Ludhiana, Mumbai, Mohali, Meerut, Madurai, Mysore, Moradabad, Noida, Nagpur, Nasik, Patna, Pathankot, Panipat, Pune, Rajkot, Ranchi, Raurkela, Rohtak, Surat, Satna, Trivandrum, Vadodara, Varanasi etc. There is hardly any city or town which is left untouched.

Real Estate has become a source of survival for many people who are either connected directly or indirectly with it. A common man who used to invest its money in buying stocks in the past has started investing in property as he foresees a good return with the way things are moving. On one hand as some people buy property for investment purpose so that the property can get them good returns in future, while there are few others who invest their money on property because they look forward to relocate. People, who invest in this sector in order to relocate from one place to another, struggle a lot since the situation becomes very complicated and difficult because of lots of belongings that include heavy & large furniture and large home appliances etc.

Whether someone moves within a city, across the city, state or overseas around the world, they need a good moving company to satisfy their necessities and help with their move. In such cases, they look out for professional packers and movers or moving companies that can help relocate easily, smoothly and with an absolute care. One can easily locate Packers and Movers in Hyderabad, Packers and Movers Chennai, Packers and Movers in Delhi, Packers and Movers in Bangalore etc. The professionals are provided with all the latest tips and techniques that make them competent in analyzing the requirements of the clients and providing utmost satisfaction. Moreover, the services are also modified in various aspects to meet the exact expectations of the clients.

Packers and Movers services are available in many cities now. People can access internet and can browse through different options available in their cities or towns. These packers and movers companies have different branches in different cities and thus anyone can use internet and browse through the different branches such as Packers and Movers Hyderabad, Packers and Movers in Chennai, Packers and Movers in Delhi, Packers and Movers in Bangalore etc. Packers and Movers is a service that demands timeliness and utmost care along with high quality relocation assistance for its customers.

Pallavi is an online Marketer. She loves to write articles and Blogs. She has written thousands of articles over internet. She loves to write about Business Directory and Packers and Movers Delhi etc.

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LA Kings beat Devils 6-1, claim 1st Stanley Cup

LOS ANGELES (AP) ? Dustin Brown practically snatched the Stanley Cup away from NHL Commissioner Gary Bettman, skating directly to center ice and thrusting it skyward.

Forgive his haste. The Los Angeles Kings' captain had only been waiting his whole life for this moment. The Kings' long-suffering fans had been waiting nearly 45 years for somebody to lift that 36-pound silver trophy and remove the burden on a franchise that had never won an NHL title.

Brown, MVP goalie Jonathan Quick and the late-blooming Kings never flinched under all that weight. After an unbelievable postseason run that ended in a triumphant flurry of blood, sweat and power-play goals in Game 6, they're all champions.

Jeff Carter and Trevor Lewis scored two goals apiece, Quick finished his Conn Smythe Trophy-winning performance with 17 saves, and the Kings beat the New Jersey Devils 6-1 Monday night, becoming the first eighth-seeded playoff team to win the Stanley Cup finals.

When Lewis scored into Martin Brodeur's empty net with 3:45 to play, the Kings' decades of tension and frustration finally turned into raw anticipation. After 45 years of existence, one tumultuous regular season and two missed chances to clinch the Cup, the Kings knew they were about to be champions for the first time.

Even the sober, serious Quick got happy.

"You get that four-goal lead, you know, it's hard for it not to creep into your head a little bit," he said. "That's when you take a big, deep breath, relax a little bit, and know it's going to happen."

The Kings can exhale. They're reigning over the NHL for the first time.

Brown had a goal and two assists for Los Angeles, which ended its spectacular 16-4 postseason run in front of a crowd including several dozen Kings faithful who have been at rinkside since the team's birth in the Second Six expansion in 1967.

"Every single guy worked so hard for us this season," said defenseman Drew Doughty, who began the year as a contract holdout and finished with six points in the finals, including two assists in the clincher. "Everyone deserves this. We got used to each other, we developed a chemistry, and we just went sailing from there."

After taking a 3-0 series lead and then losing two potential clinching games last week, the Kings finished ferociously at Staples Center just when the sixth-seeded Devils appeared capable of matching the biggest comeback in finals history.

One penalty abruptly changed the tone of the series. Brown, Carter and Lewis scored during a five-minute power play in the first period after Steve Bernier was ejected for boarding Rob Scuderi, leaving the veteran defenseman in a pool of blood. Quick took it from there, finishing a star-making two months by allowing just seven goals in six finals games.

"You never know. You get to the dance, you never know what's going to happen," Brown said. "We calmed down after losing two. It was the first time we had done that all playoffs, and we finally got off to a good start."

Rookie Adam Henrique ended Quick's shutout bid late in the second period after the Kings had built a 4-0 lead, but Lewis and Matt Greene added late goals. Brodeur stopped 19 shots for the Eastern Conference champion Devils, just the third team to force a Game 6 in the finals after falling into an 0-3 hole.

"It's disappointing, but it's been a great season for the Devils," the 40-year-old Brodeur said. "We came a long way to challenge for the Stanley Cup from not making the playoffs last year. There's only one team that can win. It's not us this time, but we're proud of what we've done."

The Kings steamrolled everyone in their path after barely making the playoffs, eliminating the top three seeds in the Western Conference in overwhelming fashion as they matched the second-fastest run to a title in modern NHL history. Although the Devils gave them a little trouble, the Kings boasted a talented, balanced roster that peaked at the absolute perfect time under midseason coaching hire Darryl Sutter.

Quick is the third American-born Conn Smythe winner, adding one more dominant game to a run in which he set NHL records for save percentage (.946) and goals-against average (1.41) among goalies who played at least 15 postseason games.

Brown, just the second American-born captain to raise the Cup after Dallas' Derian Hatcher, capped his own impressive playoff work by finishing with 20 points, tied for the postseason scoring lead with linemate Anze Kopitar. And don't forget: Brown accomplished what even Wayne Gretzky couldn't do in eight years in Los Angeles by lifting the Cup.

Brown handed off the trophy to Willie Mitchell, the 35-year-old defenseman who had never won a title. Mitchell gave it to long-injured and recently returned forward Simon Gagne, who nearly tripped before raising the Cup for the first time.

Sutter, the stone-faced Alberta farmer from a family of hockey-playing brothers, smiled like a kid at his first chance to lift the prize. Later, Brown and Justin Williams sat their crying children in the Cup, and Kopitar ? the first Slovenian NHL champion ? raised it while wearing a gold crown on his head.

After going on a 12-2 tear to the Western Conference title, the Kings won the first two games of the finals in overtime by identical 2-1 scores in New Jersey. Los Angeles then flattened the Devils 4-0 in Game 3, but missed its first chance to clinch on home ice in New Jersey's 3-1 win in Game 4.

The Devils then beat Los Angeles 2-1 in Game 5, earning another cross-country trip after becoming the first team since 1945 to win twice after falling behind 0-3 in the finals.

The Kings were the West's bottom seed after failing to clinch a playoff berth until right before their 81st game, but only because they underachieved for much of the season, spending most of it as the NHL's lowest-scoring team. The talent coalesced under Sutter, who replaced the fired Terry Murray shortly before Christmas and turned Los Angeles into a competent offensive club by late February.

Five years after the Anaheim Ducks won California's first Stanley Cup, the Golden State's oldest team raised the second. The Kings also are the first team to win the Cup at home since those Ducks, and their fans appreciated the Hollywood touch.

Despite coming off their first back-to-back losses of the playoffs, the Kings started with impressive energy in Game 6, getting most of the good early scoring chances ? and then they got the break they needed when Bernier pushed Scuderi headfirst into the boards behind Quick's net. Scuderi stayed motionless for quite a while, eventually heading to the dressing room after leaving plenty of blood from his lacerated nose.

Bernier, a 27-year-old journeyman and depth forward with two goals in 24 playoff games this season, went to the locker room. The Devils complained Jarret Stoll received no penalty for checking Stephen Gionta into the boards between the benches a moment earlier.

"I wish I could take that play back," Bernier said. "I didn't want to hurt my team. I wanted to help them. This is extremely hard. It's been a long playoff run for us. To finish on that note, it's not fun for sure. But there's nothing I can do now."

Brown scored 53 seconds into the power play, slickly redirecting Doughty's low pass in front for his first goal since the Western Conference finals opener. Carter then deflected home his seventh goal of the postseason after Brown walked the puck out of the corner and fired a shot at Brodeur's glove side while skating away from the net.

With the Los Angeles crowd on its feet, the Kings added another as rookie Dwight King ferociously drove the net and left a rebound for Lewis, who tucked it home for his first goal in 18 games. Staples Center was deafening for the rest of the first period, and Los Angeles went up 4-0 just 90 seconds into the second when Brown found Carter unchecked in the slot for a one-timer.

"It's pretty awesome," Sutter said. "It's the feeling of seeing them so happy, the work that you go through. The first thing you think about as a coach ? these guys are all young enough, they've got to try it again."

NOTES: Linemates Brown and Kopitar finished tied for the NHL postseason scoring lead with 20 points in 20 games, and fellow first-liner Williams had 11 points in the final 14 games, finishing with 15 points. ... New Jersey LW Ilya Kovalchuk, who spurned the Kings' advances two years ago to sign with the Devils, managed just one empty-net goal in six finals games. Captain Zach Parise scored his only finals point on a Game 5 goal off a misplay by Quick. ... My Chemical Romance attended the game. Their song, "Welcome to the Black Parade," has become the black-jerseyed Kings' unofficial anthem after its incorporation into a clever pregame video featuring photos of several Kings as kids.

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Black hole growth found to be out of sync

Tuesday, June 12, 2012

New evidence from NASA's Chandra X-ray Observatory challenges prevailing ideas about how black holes grow in the centers of galaxies. Astronomers long have thought that a supermassive black hole and the bulge of stars at the center of its host galaxy grow at the same rate -- the bigger the bulge, the bigger the black hole. However, a new study of Chandra data has revealed two nearby galaxies with supermassive black holes that are growing faster than the galaxies themselves.

The mass of a giant black hole at the center of a galaxy typically is a tiny fraction -- about 0.2 percent -- of the mass contained in the bulge, or region of densely packed stars, surrounding it. The targets of the latest Chandra study, galaxies NGC 4342 and NGC 4291, have black holes 10 times to 35 times more massive than they should be compared to their bulges. The new observations with Chandra show the halos, or massive envelopes of dark matter in which these galaxies reside, also are overweight.

This study suggests the two supermassive black holes and their evolution are tied to their dark matter halos and did not grow in tandem with the galactic bulges. In this view, the black holes and dark matter halos are not overweight, but the total mass in the galaxies is too low.

"This gives us more evidence of a link between two of the most mysterious and darkest phenomena in astrophysics -- black holes and dark matter -- in these galaxies," said Akos Bogdan of the Harvard-Smithsonian Center for Astrophysics (CfA) in Cambridge, Mass., who led the new study.

NGC 4342 and NGC 4291 are close to Earth in cosmic terms, at distances of 75 million and 85 million light years. Astronomers had known from previous observations that these galaxies host black holes with relatively large masses, but are not certain what is responsible for the disparity. Based on the new Chandra observations, however, they are able to rule out a phenomenon known as tidal stripping.

Tidal stripping occurs when some of a galaxy's stars are stripped away by gravity during a close encounter with another galaxy. If such tidal stripping had taken place, the halos mostly would have been missing. Because dark matter extends farther away from the galaxies, it is more loosely tied to them than the stars and more likely to be pulled away.

To rule out tidal stripping, astronomers used Chandra to look for evidence of hot, X-ray-emitting gas around the two galaxies. Because the pressure of hot gas -- estimated from X-ray images -- balances the gravitational pull of all the matter in the galaxy, the new Chandra data can provide information about the dark matter halos. The hot gas was found to be distributed widely around NGC 4342 and NGC 4291, implying that each galaxy has an unusually massive dark matter halo and that tidal stripping is unlikely.

"This is the clearest evidence we have, in the nearby universe, for black holes growing faster than their host galaxy," said co-author Bill Forman, also of CfA. "It's not that the galaxies have been compromised by close encounters, but instead they had some sort of arrested development."

How can the mass of a black hole grow faster than the stellar mass of its host galaxy? The study's authors suggest a large concentration of gas spinning slowly in the galactic center is what the black hole consumes very early in its history. It grows quickly, and as it grows, the amount of gas it can accrete, or swallow, increases along with the energy output from the accretion. After the black hole reaches a critical mass, outbursts powered by the continued consumption of gas prevent cooling and limit the production of new stars.

"It's possible that the supermassive black hole reached a hefty size before there were many stars at all in the galaxy," said Bogdan. "That is a significant change in our way of thinking about how galaxies and black holes evolve together."

The results were presented June 11 at the 220th meeting of the American Astronomical Society in Anchorage, Alaska. The study also has been accepted for publication in The Astrophysical Journal.

###

Chandra X-ray Center: http://chandra.harvard.edu

Thanks to Chandra X-ray Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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MattHardigree: RT @nickbunkley: So Ford partnered with Microsoft early on for Sync, and now most rivals are on board with Apple. It's Microsoft vs. App ...

Sorry, Readability was unable to parse this page for content.

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The New Trend For Relationships And How It Can Work For You

Marriage numbers are evolving again. For a first time marriage, the average age is getting much older. But, while there are many who are crying about traditional marriage and who is and is not threatening the concept there is something they are missing. Marriage, the institution itself is changing and not because one group wants the right and not because other groups think that it should be forced on their offspring. It is changing because people's attitudes about life, relationships and their needs are changing. One of those changes is a compromise of sorts, a way to straddle the line between being in a committed relationship and being completely single. The experts are calling it the "stay over relationship". It can work and work well, but it is a challenge that needs to be handled properly from the very start.

Almost a million adults in the United States are unmarried at any given moment, accounting for just over forty percent of the population. Nearly seventy percent of the population have zero plans of ever getting married according to recent studies. Some are opting to live with a partner while others are choosing the stay over. That entails spending three or four nights of the week at one house or the other, sometimes focusing on one home while others may alternate back and forth. It is a unique arrangement because there are often other factors that have to be considered to make the relationship work.

First, you have to understand why you are interested in a stay over relationship rather than a more traditional cohabitation or marriage. If it is financial, it is likely that eventually one or both of the parties will change their mind and make it more permanent. However, if both of you are unwilling to give up your individual space and enjoy the time that you spend together, this might be the perfect set up. Always be honest, however, especially if expectations or topics start changing. For instance, if one partner mentions eventual marriage and you know that you are never going to be interested in that, you have to let them know, immediately.

Second, there has to be guidelines. If you are okay with your furniture being rearranged, that is one thing, but if you want things where you put them, period, you need to set the ground rules. If you are not telling family members about the other person, for instance, the kids do not know, then that needs to be discussed immediately as well. Some people will continue in the stay over for decades while for others, it is only a stop gap relationship until something different comes along.

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Concussion wipes out Alberto Del Rio for No Way Out

Alberto Del Rio, the No. 1 contender to the World Heavyweight Champion Sheamus, suffered a concussion on last week?s SmackDown and will not be medically cleared to compete against Sheamus at No Way Out this Sunday,?WWE?s Breaking News mobile alert service reported Monday

According to doctors, the concussion occurred during Del Rio?s match against The Great Khali, a bout that The Mexican Aristocrat won. (PHOTOS | WATCH)

?The Great Khali did his chop to (Del Rio?s) head, which resulted in a concussion for Alberto,? said Dr. Michael Sampson. ?He didn?t get knocked out, but he did have a memory lapse and also disorientation and a neck compression, which the MRI came back as nothing but a sprain.?

Del Rio?s injury leaves open Sheamus? dance card at No Way Out. It is at this point unclear whether Raw and SmackDown General Manager John Laurinaitis has a replacement in mind to face The Celtic Warrior. However, with WWE Chairman Mr. McMahon set to evaluate Laurinaitis? job performance on tonight?s special three-hour edition of Raw SuperShow, which begins at 8/7 CT, a new No. 1 contender is expected to be announced.

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Video: What If Greece Leaves?

Greece and the world of finance are bracing for this weekend's election, with CNBC's Michelle Caruso-Cabrera.

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Epson BrightLink 485Wi

The Epson BrightLink 485Wi ($2,200 street) is far more than just another ultra short throw interactive projector. Among its more interesting features are automatic calibration, the ability to use two interactive pens simultaneously, and the extension of the interactive whiteboard feature to work with other image sources besides computers. The result is a step ahead of the competition in many ways, and also an Editors' Choice.

Like the Editors' Choice Hitachi BZ-1 ($1.795, 4.5 stars), the 485Wi is LCD-based, which means it shares some of the same advantages and disadvantages. Under disadvantages, file the lack of 3D support. Although more and more DLP projectors today, including the Editors' Choice Optoma TW675UTi-3D ($1800 street, 4 stars), offer the feature, 3D isn't available yet in any LCD data projectors. If you need it, this pretty much rules out the 485Wi.

On the other hand, LCD projectors don't suffer from rainbow artifacts, with light areas breaking up into little red-green-blue rainbows. These artifacts result from the way single-chip DLP projectors produce color. Some people see them more easily than others, but if you don't need 3D, you can guarentee that no one in your audience will be annoyed by them simply by picking an LCD projector like the 485Wi.

The Basics, Portability, and Setup
The 485Wi offers WXGA (1280 by 800) native resolution and a 3100 lumen rating. As with most interactive ultra short throw projectors today, it's designed so you can mount it either horizontally or vertically, facing straight down, to create an interactive table top. According to Epson, the cooling system works just as well in either orientation.

Measuring 5.7 by 14.5 by 14.8 inches (HWD) and weighing 11.9 pounds, the projector can sit on a cart for room to room portability, but it's meant primarily for permanent installation. In fact, one of the reasons it costs more than most of its competition is that, unlike most, it comes with a mount. You even have the choice of buying it with either a wall mount or tabletop mount.

Except for the 485Wi's interactive feature, setup is absolutely standard. Connection options for images include an HDMI port for a computer or video source; two VGA ports for computers or component video; both S-video and composite video ports; and a USB A port?for a document camera, for sending images directly from a computer, or for reading files directly from a USB memory key. In addition, you can send images over a LAN connection.

Enhanced Interactive Features

One advantage that most DLP interactive projectors have over LCD projectors is that they use TI's approach to interactivity, which doesn't need to calibrate the pen and projector. The 485Wi not only needs calibration, it needs to recalibrate every time you move the projector, change resolution, or change the image size.

The good news is that calibration with the 485Wi is fully automatic, which is the next best thing to not needing it at all. Simply press two buttons on the remote and wait about 10 seconds while the projector puts a calibration image on screen, analyzes it, and recalibrates.

The automatic calibration is only one of the 485Wi's extras. Unlike most interactive projectors, it comes with two interactive pens rather than one?another additional piece of hardware that helps justify the price. More important, it lets you work with both pens at once, so two people can interact with the screen, adding notations simultaneously. This is particularly useful with an interactive tabletop, with people seated around the table.

Still another new feature, adding up to a hat trick, is the ability to interact with image sources besides computers. An annotation mode in firmware lets you mark up images from any source, including, for example, Blu-ray players and iOS devices (with plans to include Android devices shortly). You can even freeze a video image, so you can mark up the frame. The player will keep going, though, so when you unfreeze the image, you'll pick up at some later point in the video.

Big Picture, Short Distance, High Image Quality
The most impressive feature for any ultra short throw projector, of course, is the ultra short throw. For my tests, to get a 78-inch wide (93-inch diagonal) image at the native 16:10 aspect ratio, I had to put the projector all of 10 inches from the screen. According to Epson, the full range for image size is 60 to 100 inches diagonally, at 2.5 to 12.2 inches from the screen.

The 3100 lumen rating is a touch less than the Optoma TW675UTi-3D ?offers, at 3200 lumens. However, unlike the Optoma projector, the 485Wi lets you interact at full brightness, rather than using a separate interactive mode with a lower brightness. In my tests, the 93-inch diagonal image was easily bright enough to stand up to typical levels of ambient light in a conference room or classroom.

Image quality also counts as a strong point for the 485Wi, particularly for data images. The projector handled our standard suite of DisplayMate tests nicely, with vibrant, fully saturated color; excellent color balance with suitably neutral grays at all shades from black to white, and reasonably crisp, highly readable text even at small font sizes.

You won't mistake the video quality for something coming out of a home theater projector, but it's good for a data projector, and good enough to be watchable, thanks in large part to the lack of rainbow artifacts. The 485Wi did a particularly good job for a data projector with shadow detail (details based on shading in dark areas), and I saw little to no posterization (shading changing suddenly where it should change gradually) even in scenes than many data projectors tend to posterize.

With all of its strengths, the Epson BrightLink 485Wi is shoo-in for Editors' Choice, standing alongside the TW675UTi-3D and BZ-1. If you need 3D, the TW675UTi-3D is the only one of the three that offers it, making it the obvious pick. Similarly the BZ-1 is the most portable of the three, and it can save you some money if you don't want to pay for a mount or second pen that you don't need. But if you don't need 3D, and you're planning to mount the projector permanently, the Epson BrightLink 485Wi is a compelling pick, with a bright, high quality image plus innovative features, including automatic calibration and the extension of interactivity to any image source.

More Projector Reviews:
??? Acer H6500
??? Epson BrightLink 485Wi
??? AAXA P3
??? Acer C120 Projector
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PwC: Entertainment & Media Spend Was $1.6 Trillion in 2011; Will Rise To $2.1T By 2016 With Digital Leading Growth

Global spend on entertainment and media services, according to a new Global Media and Entertainment Outlook report out from PwC, will reach $2.1 trillion by 2016, from $1.6 trillion in 2011. But the continuing shift to digital over physical distribution will mean that growth will come at a slower pace than in previous years -- and at a rate slower than that of overall GDP, 5.7 percent versus 6.6 percent. PwC says digital spend will generate 67 percent of E&M spendng growth in the next five years. Ironically, although the move to digital means more efficiency and therefore less spend on entertainment and media services, that trend is actually helping some sectors: music, led by digital purchases, will rise (modestly) in 2013 after years of decline. PwC says that digital accounted for one-third of all recorded music spend in 2011, and it will overtake global spend on physical music (CDs mainly) in 2015. Similarly, PwC notes that spend on digital ads for consumer magazines will offset declines in print ads for that sector.

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Xbox 360 spring update rolling out to some now, everyone else next week

It doesn't bring quite the overhaul that previous updates have, but at least some Xbox 360 users should be seeing a new software update available the next time they turn on their console. Xbox's Major Nelson confirmed on Twitter today that the spring update is rolling out to "a few" users this week, with everyone else set to receive it next week. As for details on the update, he's only gone as far as to confirm that it contains "behind the scenes improvements & prep for future enhancements." Presumably, those future enhancements include many of the new features we saw at E3 last week, but there's still no official word as to when they'll actually roll out.

Xbox 360 spring update rolling out to some now, everyone else next week originally appeared on Engadget on Tue, 12 Jun 2012 15:43:00 EDT. Please see our terms for use of feeds.

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Oil above $86 as Spain gets funds to rescue banks

SINGAPORE (AP) ? Oil jumped above $86 a barrel Monday in Asia after Europe offered Spain a $125 billion rescue loan for its troubled banks.

Benchmark oil for July delivery was up $2.00 to $86.10 per barrel at midday Singapore time in electronic trading on the New York Mercantile Exchange. The contract fell 72 cents to settle at $84.10 in New York on Friday.

In London, Brent crude for July delivery was up $2.09 at $100.56 per barrel on the ICE Futures exchange.

Over the weekend, the 17 countries that use the euro common currency pledged to lend Spain funds to bailout out its faltering banks. Oil has dropped from $106 last month as Spain's banking crisis threatened to worsen Europe's economic slowdown, which would weaken demand for crude.

The financial lifeline for Spain helped strengthen the euro to $1.2635 from $1.2507 late Friday in New York. A weaker dollar makes commodities priced in dollars less expensive for investors with other currencies.

"Over the last three months we have seen a significant reemergence of the link between the euro and oil prices," energy trader and consultant The Schork Group said in a report. "Thus, strength in the euro likely means support for oil prices."

A warning from Iran that negotiations over its nuclear program could stall also helped raise oil prices. Ali Bagheri, Iran's No. 2 nuclear negotiator, said Western powers must explain what concessions it will offer to Iran in return for a halt to upgrading enriched uranium to weapons grade, according to official IRNA news agency Sunday.

Iran and six world powers are scheduled for talks in Moscow on June 18.

Iran says it is developing a nuclear program for peaceful purposes. In exchange for discussing enrichment, Iran wants the West to ease sanctions which have made exporting its crude more difficult.

In other energy trading, heating oil was up 4.6 cents at $2.72 per gallon while gasoline futures rose 4.7 cents at $2.73 per gallon. Natural gas slid 3 cents at $2.27 per 1,000 cubic feet.

___

Follow Alex Kennedy on Twitter at http://twitter.com/alexkennedy_ap

Associated Press

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thomas_w_: RT @dandad: A little something for everyone in #England today. London Fog and Gentle Summer Rain. 1968. http://t.co/tbnIlrqt

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Texas offers $5.7M in grants for alt fuel vehicles

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New Mexico, Colorado fires burn out of control

BELLVUE, Colo. ?

The U.S. Forest Service says it is adding more aircraft to its aerial firefighting fleet to help battle wildfires in the West.

Forest Service Chief Tom Tidwell said Monday the service is contracting one air tanker from the state of Alaska and four from Canada. Two more air tankers are being activated in California.

Tidwell says the temporary additions will make 17 air tankers available to the Forest Service.

The service has deployed 10 air tankers, 62 helicopters and 4,000 personnel to more than 100 fires nationwide, including large fires in Arizona, Colorado and New Mexico.

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

Massive wildfires in drought-parched Colorado and New Mexico tested the resources of state and federal crews Monday and underscored the need to replenish an aging U.S. aerial firefighting fleet needed to combat a year-round fire season.

Wyoming diverted personnel and aircraft from two fires there to help with a 60-square-mile wildfire in northern Colorado. Canada also loaned two aerial bombers to fight the Colorado blaze following the recent crash of a U.S. tanker in Utah. And an elite federal firefighting crew arrived to try to begin containing a fire that destroyed at least 118 structures.

All told, about 600 firefighters will be battling the fire some 15 miles west of Fort Collins by Tuesday, said incident commander Bill Hahnenberg. "We are a very high priority nationally. We can get all the resources we want and need," he said.

But Colorado's House congressional delegation demanded that the U.S. Forest Service deploy more resources to the fire, which was zero percent contained and forced hundreds of people to abandon their homes. One person was missing.

In a letter to the Forest Service, Colorado's congressmen said the need for firefighting aircraft was "dire." Colorado U.S. Sen. Mark Udall urged President Barack Obama to sign legislation that would allow the Forest Service to contract at least seven large air tankers to add to its fleet of 13 - which includes the two on loan from Canada.

One of the region's most potent aerial firefighting forces - two Wyoming Air National Guard C-130s fitted to drop slurry - sat on a runway in Cheyenne, 50 miles north of the Colorado fire. The reason: The U.S. Forest Service, by law, cannot call for military resources until it deems that its fleet is fully busy. It also takes 36 hours to mobilize the crews and planes, officials said.

"They just haven't thrown the switch yet because they feel like there are adequate resources available," said Mike Ferris, a spokesman for the National Interagency Fire Center in Boise, Idaho.

Colorado was using five of 13 air tankers available nationally, said Forest Service spokesman Steve Segin.

Meanwhile, helicopters were used to suck water from a reservoir and drop it on nearby homes dangerously close to the flames.

Evacuees expressed gratitude for the help.

"They're doing the best they can," said Barb Hermsen as she watched a helicopter make daring raids through smoke and flame to protect homes. "We know how much they have to go through, and where they're going - man, it's crazy."

In New Mexico, firefighters got new air and ground support to battle a fast-moving wildfire that charred tens of thousands of acres and forced hundreds of residents to leave their homes in the southern part of the state.

Smoke filled the air in the mountain community of Ruidoso as evacuees gathered at a high school gymnasium to get an update on the lightning-sparked fire in the Sierra Blanca mountain range. The blaze exploded over the weekend and reached more than 54 square miles by Monday.

An estimated 35 structures have been damaged or destroyed by the blaze, and fire managers expect that number to grow once damage assessments are done.

Elsewhere in New Mexico, firefighters made slow progress against the largest wildfire in state history. The blaze has charred 435 square miles of forest since it was sparked by lightning in mid-May, and was 37 percent contained Monday.

Arizona's state forestry division dispatched two water tenders and 15 fire trucks to New Mexico, which also welcomed the arrival of a DC-10 jetliner that can lay a 100-yard-wide, mile-long line of retardant or water.

Fire bosses in New Mexico and Arizona ordered more elite crews, engines and air support from the Southwest Coordination Center in Albuquerque, where director Kenan Jaycox said resources are approaching full capacity.

"It's a balancing game," Jaycox said.

At least 18 large wildfires are burning in nine U.S. states, forcing the reshuffling of fire crews and aircraft. The National Interagency Fire Center in Boise, Idaho, said 4,000 of 15,000 federal firefighters are currently deployed at fires around the country.

Because aircraft were scarce, federal fire managers asked Wyoming to send National Guard helicopters to a 6-square-mile wildfire in Guernsey State Park. In nearby Medicine Bow National Forest, crews containing a 13-square-mile fire sent air support to Colorado.

U.S. Forest Service Chief Tom Tidwell has long insisted the federal government has enough resources to respond to a year-round wildfire season driven by drought, heat, decades of fighting forest fires rather than letting them run their natural course, and bark beetle pine tree kill.

"We have enough resources at this time to be able to deal with the fires we currently are dealing with and what we expect to have to deal with the rest of this fire season," Tidwell told The Associated Press last week. He emphasized that the forest service has the authority to transfer funds from other accounts to meet firefighting costs in any given year.

Some 1,459 square miles have burned across the country this year - less than the same period in 2011, when 6,327 square miles burned.

---

Associated Press writers Susan Montoya Bryan in Albuquerque, N.M.; Felicia Fonseca in Flagstaff, Ariz.; and Mead Gruver in Cheyenne, Wyo., contributed to this report.

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California dreaming turns real as Kings hoist Cup

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You have grandpa's chromosome tips

Older fathers pass more gene-protecting DNA to their paternal grandkids

Web edition : 4:27 pm

Men who become fathers later in life may pass a mark of longevity down to their paternal grandchildren.

As men age, their chromosomes are tipped with longer telomeres ? structures that protect valuable genetic information from deterioration during cell division and other processes. Longer telomeres have been associated with long life, whereas short telomeres have been linked to aging and disease. ?

Scientists have known for a while that telomeres increase in length for every year a man ages and that children of older dads inherit longer telomeres. But the new study by researchers at Northwestern University in Evanston, Ill., extends that inheritance to grandchildren. The new finding, published online June 11 in the Proceedings of the National Academy of Sciences, could point to a mechanism by which men can influence the health of their offspring for generations.

?It?s a provocative finding and it?s well done on so many levels,? says Ken Smith, a biodemographer at the University of Utah in Salt Lake City. But, Smith says, there is ample evidence that having an older father also puts children at greater risk for autism, schizophrenia, some cancers (SN: 3/29/08, p. 200) and other diseases. Some of those diseases may result in part from mutations that accumulate in sperm as a man ages. It is unclear if inheriting longer telomeres can offset the potential downsides of having an aging father or grandfather, he says.

In the new study, the Northwestern researchers studied multigenerational families from the Philippines, measuring the average length of telomeres in more than 2,000 people. A father?s age at birth influenced the length of the children?s telomeres, with older fathers having kids with longer telomeres. Both sons and daughters got the telomere boost from dear old dad, but the long chromosome caps were bequeathed on grandchildren mainly through the paternal line. The data gave a hint that maternal grandfathers influence their grandchildren?s telomere length, but the link didn?t pass statistical muster.

?One of the mysteries of the study is why it doesn?t come from the maternal grandfather,? says Northwestern biological anthropologist Dan Eisenberg.

The team did not study the relationship between telomere length and health. The researchers hope to replicate the findings in other groups of people.

Found in: Genes & Cells

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Scripps Florida scientists identify new molecules important for vision and brain function

Public release date: 11-Jun-2012
[ | E-mail | Share ]

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

JUPITER, FL, June 11, 2010 In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified several proteins that help regulate cells' response to lightand the development of night blindness, a rare disease that abolishes the ability to see in dim light.

In the new studies, published recently in the journals Proceedings of the National Academy of Sciences (PNAS) and The Journal of Cell Biology, Scripps Florida scientists were able to show that a family of proteins known as Regulator of G protein Signaling (RGS) proteins plays an essential role in vision in a dim-light environment.

"We were looking at the fundamental mechanisms that shape our light sensation," said Kirill Martemyanov, a Scripps Research associate professor who led the studies. "In the process, we discovered a pair of molecules that are indispensible for our vision and possibly play critical roles in the brain."

In the PNAS study, Martemyanov and his colleagues identified a pair of regulator proteins known as RGS7 and RGS11 that are present specifically in the main relay neurons of the retina called the ON-bipolar cells. "The ON-bipolar cells provide an essential link between the retinal light detectorsphotoreceptors and the neurons that send visual information to the brain," explained Martemyanov. "Stimulation with light excites these neurons by opening the channel that is normally kept shut by the G proteins in the dark. RGS7 and RGS11 facilitate the G protein inactivation, thus promoting the opening of the channel and allowing the ON-bipolar cells to transmit the light signal. It really takes a combined effort of two RGS proteins to help the light overcome the barrier for propagating the excitation that makes our dim vision possible."

In the Journal of Cell Biology study, Martemyanov and his colleagues unraveled another key aspect of the RGS7/RGS11 regulatory responsethey identified a previously unknown pair of orphan G protein-coupled receptors (GPCRs) that interact with these RGS proteins and dictate their biological function.

GPCRs are a large family of more than 700 proteins, which sit in the cell membrane and sense various molecules outside the cell, including odors, hormones, neurotransmitters, and light. After binding these molecules, GPCRs trigger the appropriate response inside the cell. However, for many GPCRs the activating molecules have not yet been identified and these are called "orphan" receptors.

The Martemyanov group has found that two orphan GPCRsGPR158 and GPR179recruit RGS proteins and thus help serve as brakes for the conventional GPCR signaling rather than play an active signaling role.

In the case of retinal ON-bipolar cells, GPR179 is required for the correct localization of RGS7 and RGS11. Their mistargeting in animal models lacking GPR179 or human patients with mutations in the GPR179 gene may account for their night blindness, according to the new study. Intriguingly, in the brain GPR158 appears to play a similar role in localizing RGS proteins, but instead of contributing to vision, it helps RGS proteins regulate the ?-opioid receptor, a GPCRs that mediates pleasurable and pain-killing effects of opioids.

"We are really in the very beginning of unraveling this new biology and understanding the role of discovered orphan GPR158/179 in regulation of neurotransmitter signaling in the brain and retina," Martemyanov said. "The hope is that better understanding of these new molecules will lead to the design of better treatments for addictive disorders, pain, and blindness."

###

The first author of the PNAS study, "Regulators of G Protein Signaling RGS7 and RGS11 Determine the Onset of the Light Response in ON Bipolar Neurons" is Yan Cao of The Scripps Research Institute. Other authors include Johan Pahlberg and Alapakkam P. Sampath of the University of Southern California; Ignacio Sarria of The Scripps Research Institute; and Naomi Kamasawa of the Max Planck Florida Institute.

The first author of the Journal of Cell Biology study, "GPR158/179 Regulate G Protein Signaling by Controlling Localization and Activity of the RGS7 Complexes" is Cesare Orlandi of The Scripps Research Institute. Other authors include Ekaterina Posokhova and Ikuo Masuho of The Scripps Research Institute and Thomas A. Ray, Nazarul Hasan, and Ronald G. Gregg of the University of Louisville, Kentucky.

Both studies were supported by the National Institutes of Health. The PNAS study was also supported by the McKnight Endowment Fund for Neurosciences

The first study was published in the May 15, 2012 issue of the journal Proceedings of the National Academy of Sciences. The second study was published June 11, 2012 by The Journal of Cell Biology.

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Public release date: 11-Jun-2012
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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

JUPITER, FL, June 11, 2010 In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified several proteins that help regulate cells' response to lightand the development of night blindness, a rare disease that abolishes the ability to see in dim light.

In the new studies, published recently in the journals Proceedings of the National Academy of Sciences (PNAS) and The Journal of Cell Biology, Scripps Florida scientists were able to show that a family of proteins known as Regulator of G protein Signaling (RGS) proteins plays an essential role in vision in a dim-light environment.

"We were looking at the fundamental mechanisms that shape our light sensation," said Kirill Martemyanov, a Scripps Research associate professor who led the studies. "In the process, we discovered a pair of molecules that are indispensible for our vision and possibly play critical roles in the brain."

In the PNAS study, Martemyanov and his colleagues identified a pair of regulator proteins known as RGS7 and RGS11 that are present specifically in the main relay neurons of the retina called the ON-bipolar cells. "The ON-bipolar cells provide an essential link between the retinal light detectorsphotoreceptors and the neurons that send visual information to the brain," explained Martemyanov. "Stimulation with light excites these neurons by opening the channel that is normally kept shut by the G proteins in the dark. RGS7 and RGS11 facilitate the G protein inactivation, thus promoting the opening of the channel and allowing the ON-bipolar cells to transmit the light signal. It really takes a combined effort of two RGS proteins to help the light overcome the barrier for propagating the excitation that makes our dim vision possible."

In the Journal of Cell Biology study, Martemyanov and his colleagues unraveled another key aspect of the RGS7/RGS11 regulatory responsethey identified a previously unknown pair of orphan G protein-coupled receptors (GPCRs) that interact with these RGS proteins and dictate their biological function.

GPCRs are a large family of more than 700 proteins, which sit in the cell membrane and sense various molecules outside the cell, including odors, hormones, neurotransmitters, and light. After binding these molecules, GPCRs trigger the appropriate response inside the cell. However, for many GPCRs the activating molecules have not yet been identified and these are called "orphan" receptors.

The Martemyanov group has found that two orphan GPCRsGPR158 and GPR179recruit RGS proteins and thus help serve as brakes for the conventional GPCR signaling rather than play an active signaling role.

In the case of retinal ON-bipolar cells, GPR179 is required for the correct localization of RGS7 and RGS11. Their mistargeting in animal models lacking GPR179 or human patients with mutations in the GPR179 gene may account for their night blindness, according to the new study. Intriguingly, in the brain GPR158 appears to play a similar role in localizing RGS proteins, but instead of contributing to vision, it helps RGS proteins regulate the ?-opioid receptor, a GPCRs that mediates pleasurable and pain-killing effects of opioids.

"We are really in the very beginning of unraveling this new biology and understanding the role of discovered orphan GPR158/179 in regulation of neurotransmitter signaling in the brain and retina," Martemyanov said. "The hope is that better understanding of these new molecules will lead to the design of better treatments for addictive disorders, pain, and blindness."

###

The first author of the PNAS study, "Regulators of G Protein Signaling RGS7 and RGS11 Determine the Onset of the Light Response in ON Bipolar Neurons" is Yan Cao of The Scripps Research Institute. Other authors include Johan Pahlberg and Alapakkam P. Sampath of the University of Southern California; Ignacio Sarria of The Scripps Research Institute; and Naomi Kamasawa of the Max Planck Florida Institute.

The first author of the Journal of Cell Biology study, "GPR158/179 Regulate G Protein Signaling by Controlling Localization and Activity of the RGS7 Complexes" is Cesare Orlandi of The Scripps Research Institute. Other authors include Ekaterina Posokhova and Ikuo Masuho of The Scripps Research Institute and Thomas A. Ray, Nazarul Hasan, and Ronald G. Gregg of the University of Louisville, Kentucky.

Both studies were supported by the National Institutes of Health. The PNAS study was also supported by the McKnight Endowment Fund for Neurosciences

The first study was published in the May 15, 2012 issue of the journal Proceedings of the National Academy of Sciences. The second study was published June 11, 2012 by The Journal of Cell Biology.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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